Quantification of heat shock proteins in the posterior interosseous nerve among subjects with type 1 and type 2 diabetes compared to healthy controls

Introduction Diabetic peripheral neuropathy (DPN) is a common complication of both type 1 (T1D) and 2 diabetes (T2D). No cure for DPN available, but several potential targets have been proposed treatment. Heat shock proteins (HSPs) are known to respond hyper- hypoglycemia. can be diagnosed using electrophysiology studied nerve biopsies. Aim This study aimed analyze the presence patterns HSPs in biopsies from subjects with T1D, T2D, healthy controls. Methods Posterior interosseous nerves (PIN) total 56 T1D ( n = 9), T2D 24), without (i.e., controls, 23) were harvested under local anesthesia prepared quantitative mass spectrometry analysis. Protein intensities associated data ulnar morphometry same PIN, differences protein between groups analyzed. Results In total, 32 different identified quantified specimens. statistically significant observed regarding groups. Furthermore, did not correlate amplitude or conduction velocity myelinated fiber density PIN. Conclusion Quantitative proteomics used biopsies, no clear quantities this cohort.